9.1.16

Master “The Nude No Makeup” Trend For 2016


How to look good without makeup
“The natural look” or as they call it “Nude On Nude” trend is gaining popularity these days, as young and genetically blessed models/celeb selfies are going viral with “dare to bare”, “I wear no make up”, “I woke up like this”, yup “I am A Natural BEAUTY”, and “I don’t care” attitude on social media.  I want to be a cheerleader to this “no makeup” campaign, but the only snag I see while practicing this ultimate barefaced trend is that it requires flawless skin almost close to perfection — not every one inherits perfect skin from their mamma.

No need to pout! Even if you’re not on the genetically endowed list, let aesthetic science show you once and for all how the ultimate barefaced look can be nailed.

How To Achieve Flawlessly Smooth Skin?

Our skin is the primary barrier that protects our body against assaults from the outside world. Toxins and dead cells accumulate on the skin’s surface and stop it from breathing, which causes skin problems such as seborrhoea, acne, a dull complexion, pigmentation marks, blackheads and enlarged pores. UV rays from sun along with hormonal changes cause skin pigmentations, melasma and photo-damage. To keep skin at its optimal and reverse daily skin damage the solution lies in regularly exfoliating the skin, thus encouraging skin renewal. Laser peels in my opinion do this job with excellent precision and utmost control— according to the parameters selected, we can choose how deep we want to work, how much skin surface area we want to cover and how much heat we want to deposit in the skin to denature old and damaged collagen and start the process of new collagen synthesis. All these controlled parameters give way to superior results, which are lacking when we go for chemical peels. Additionally the heat component stimulates the skin’s cells to produce new dermal collagen that imparts youth to skin. Thus the treated skin looks smoother and more radiant, and at the same time we benefit from photo-rejuvenation effects of laser light.
One laser peel gives the same, or even better, results than a 5-10 series of diamond dermabrasion treatments or chemical peels.

In addition to laser skin smoothing people with oily and acne prone skin need to use special skincare on daily basis to calm their oil glands in order to prevent future open pores, black heads and acne.

How To Keep The Promise Of A Clear Complexion?

Pigmentation marks, scars, redness, melasma and spider veins are common flaws that need to be addressed before embarking on barefaced trend.

Creating smooth and perfect skin with lasers

For pigmentation patches lasers again happen to be the tool of choice, the laser chosen depends on the color of the skin and the location of the mark, which might be dermal or epidermal. The lasers used are Q-switched KTP, Nd:Yag, Alexandrite, Fraxel or Fractional CO2 and Erbium ablative lasers.

Vascular flaws can be eliminated using KTP, Nd:Yag or PDL (pulsed dye laser) lasers.

Fractional CO2 and erbium ablative lasers can be used to treat scarring.

Restoring Contours & Smoothing out Facial Imperfections

Categorically perfect face means a visage without wrinkles contoured with golden proportions with shapely volumes.

We can achieve facial contour harmony with the help of injectable essentials like Botulinum toxin and hyaluronic acid.  Botox works like magic to tame down dynamic wrinkles and hyaluronic acid happens to be the perfect additive to achieve seamless and smooth well-proportioned face to restore volume and erase wrinkles in the cheeks, under-eye area, lips and chin areas.

A perfect mouth and eyes are considered unparalleled weapons of seduction. If you are planning to quit lipstick, lip lining and concealer under-eyes you have to make sure your lips are well defined with right volume at the right places and that the delicate skin under your eyes is smooth and wrinkle as well as pigmentation free. A combination of ablative lasers to iron our wrinkles and pigmentation around the eyes, as well as hyaluronic acid injections in the under the eyes area can help erase a tired expression. Hyaluronic acid can also be used into the eyebrows to reshape and reposition the brows and into the lips to recover lost volume, give more alluring shape and sensuality.

Hydration Is The Key To Immaculate Skin

The first step to a flawless complexion is hydration, to intensely hydrate the skin, we can use non cross-linked hyaluronic acid alone or coupled with multivitamins and skin boosters.

Juvederm Hydrate

Non Cross-Linked Hyaluronic Acid in the form of Skinboosters by Juvederm Hydrate, Teosyal Meso, Boletero can be injected into the mid-dermal layer to increase skin hydration as one molecule of HA brings in 800 molecules of water. The aim is to create denser-looking skin without affecting the facial features or volumes. The skin’s structure is reinforced in the form of elasticity, firmness and radiance. Skin dermis is hydrated. Usually two to three sessions are carried out, leaving a month in between, followed by one or two top-up sessions per year.

Mesotherapy skin boosting injections filled with nourishing and revitalizing complexes containing vitamins, antioxidants and hyaluronic acid are available as special cocktails ready to be injected into the superficial dermis to increase skin hydration as well as nourishing the skin. The face, neck, décolletage, back of the hands and the body can all be treated with such cocktails to give glow and radiance to the skin.

Now You Are Ready To Pose San Makeup And Click A Selfie

Perfect Selfie

Enjoy your nude on nude look, Bye-bye layers of makeup, contouring kits and concealers the aesthetc medicine has leveled the playing field between genetically endowed and nawt.

24.12.15

BRAUN BEAUTY GIRLS NIGHT IN JEDDAH


Brau events Dr. Shazia Ali
BRAUN Reveals Its Complete Beauty Collection At An Exclusive Event 
KSA, November 2015 – Braun the world’s No. 1 epilator brand hosted an experiential event in Jeddah, which was attended by some of the most influential beauty and fashion leaders in KSA. The experiential beauty event “Braun Beauty Girls Night In” was the first of its kind as Braun highlighted that when women feel confident they can realize their potential, wear anything they want and embrace unlimited choices.
Braun revealed the Silk-épil 5 the latest addition to the Braun beauty collection, the Silk-épil 9 Wet & Dry, the ultimate portable skin spa and beauty essential every woman needs to look and feel their best was also available for the ladies to experience and finally, the guests were given a chance to customize their skin care regimen and switch on a Hollywood flawless glow by using the Braun Face and the latest beauty brushes.
Braun event Saudi Arabia

Guests were transformed from girl next door to a glam Braun Beauty as they were given an in depth skin consultation with renowned dermatologist, Dr. Shazia Ali and were also treated to a complete make over from beauty specialist Inas Hammoud.
Associate Brand Director from Braun’s Global team, Leonara Scarpa attended the event and was eager to talk to the ladies about Braun’s BreakFree Campaign which called on women worldwide to support and encourage each other, ” We are excited to showcase the Braun beauty collection at this beautiful event today. The Braun Silk-épil line up which includes Silk-épil 9, Braun Face and now Silk-épil 5 truly is a customized approach to beauty regimes. At Braun we strive to provide women with the latest beauty essentials that can help them take control of their beauty routine.”
To sum it up, the event was an enjoyable and informative evening for all the guests as it gave them a chance to experience the entire Braun beauty collection as well as look and feel Beautiful.
Braun events dr shazia ali

Braun events dr shazia ali
Braun event dr shazia aliBraun events dr shazia ali

16.12.15

How To Keep Your Chin Up In Today’s Beauty Obsessed World


Juvederm for chin
Connoisseurs of beauty agree that a good facial architecture is necessary to emphasize the allure of any face whether you’re a man or a woman. Inspired by the beauty criteria prescribed by poets and painters women have been obsessing over sexy lips, long lashes, high cheek-bones, etc. but recently the renaissance sculptors — a.k.a the aesthetic doctors of today — have diverted attention towards the lower face focusing on chin and jaw-line.

Exhibit One Kim K — looking at these before and after’s you can clearly see that the position of chin is fundamental when judging the golden proportions of a face. 
kim kardasian chin enhancement
A youthful V-shaped face blessed with well angled/sized chin can elevate beauty of any visage if the correct proportions are restored.

Hot Or Not Finger Trap Test — Lets put your beauty to a bone fide “Rickett's E-line” test to verify your lower facial symmetry and proportions. For a quick determine if you're 'beautiful' —place your index finger against your chin and nose and see if your lips touch it. If they do, congratulations, you're officially hot.
#DrShaziaAli

This concept of measuring lower face proportions dates back to the 1950s and is credited to orthodontist Dr. Robert Ricketts, who focused on what he called the 'E-plane'. According to him in an average Caucasian face a  'pleasing facial profile' was determined — when a simple line drawn from the tip of the nose to the tip of the chin, the lips touched the plane — or in the finger trap's case, the finger- running from the nose to the chin. Like the Golden Ratio devised by the ancient Greeks, its one of the tests practiced by some cosmetic doctors to assess and plan cosmetic treatments.

Reality Of Life Not everyone is born with a perfect facial structure. Some of us are born with a recessive or weak chin. Aging can also play a role as lax skin and the effects of gravity disrupt the contours of a once beautiful face. Fat layers on the form of a double chin can also distort the beauty and elegance of a face.

Proportions of Chin

Facial proportions

Non Surgical Solutions

Liquid Implants like Hyaluronic Acid (Juvéderm® Ultra Xc, Juvéderm Voluma®, Teosyal Ultra Deep) and Calcium Hydroxyapatite (Radiesse) can be expertly injected to define the golden proportions of chin in contrast to the face.

chin injections

Fat Injections a natural option that can also be used to reshape and volumize a recessive chin and restore the golden proportions of chin.

Aesthetic medicine now can non-surgically give you, what only genetically blessed people had it naturally in the past. Enjoy the reaps of modern medicine balance your inner beauty with your outer beauty and smile bright.

6.12.15

Strangle Yourself Thin — The Waist Training Trend


Waist training
The corset— that symbol of 19th-century patriarchal oppression and torture has been experiencing a bit of a comeback and Hollywood along with its zaftig partners-in-crime: the Kardasian clan have been taking full credit for it. Lily James starring as Cinderella recently ignited a serious debate on all social media platforms, which circled particularly around her 17inch cinched-waistline — naturally slim or corset magic? Our latest obsession with waif waistlines is not a new fad, in fact it is a boomerang effect as if a subliminal message has been passed back to us through centuries: Be it a Disney princess, Victorian era heroine,  a modern day working gal or a reality TV princess a minuscule waistline elevates female-form imparting it with a magical edge ascending gal-next-door to the status of an ethereal beauty at some level we all crave it unconsciously— don't you?
waist training

Since corset training to curb mum-tums has become all the rage, celebs like Jesica Alba, JWoww, Ciara and Brooke Burke-Charvet all have professed to practice and believe in the power of a corset cinched waist. Inspired eves in Jeddah have been popping into my practice in throws inquiring about the legitimacy of this dernier cri, hence I have decided to write about it, so you can all know my view on this fad once and for all.

What is Waist Training?
Corset training draws on the age-old Elizabethan trend used by women to cinch their waists and make their busts appear larger. Modern corsets used for “waist training,” (the fitness buzzword) combine the traditional structure of corsets to give the illusion of a tinier waist with the modern technology of compression fabric. Theoretically speaking the compression fabric encourages thermal activity and perspiration to help stimulate weight and inch loss in the core. 

The Hardcore Truth— You don’t have to be an M.D. to realize that “training” your waist to shrink in size permanently sounds suspiciously iffy. While you are wearing the corset fat is simply pushed to another area of the body for a temporary amount of time. Once you take the garment off, your body will return to its usual size. The fix is temporary.
Believers say that the tightness of the garment makes you sweat a lot, but scientifically speaking it’s really not possible to perspire so much that inches can get shaved off from your midsection in any permanent way. There is also the theory that the stomach will be squeezed into a smaller size, causing less hunger and less overall intake of calories with weight loss as a result.
So far there is no clinical proof, that thermal effect, or squeezing the tummy can be effective or beneficial in reducing fat permanently. In fact, it may be harmful to a woman’s body over time. If a waist trainer is too tight; which many of them appear to be (if recent celeb photos are any indication) it could cause discomfort, interfere with breathing, or contribute towards heartburn. Your stomach might get pushed up beyond the diaphragm, which could cause acid reflux or hernia.

Weighing The Risks— Let’s explore the possible risks involved in this new slimming craze. As a corset squeezes a woman’s outsides, it is also squeezing the insides. This pressure on the internal organs can be a serious health concern. If the lungs are prevented from properly expanding, it can increase risk of pneumonia. As the stomach and colon are prevented from moving its contents, heartburn and chronic constipation can occur. Forcing the ribs and muscles into a tight and restrictive garment can cause chronic pain and bruising. The corset can also prevent return of blood flow to the heart, which can affect blood pressure and may result in dizziness and even fainting. Homes in the 18th century had "fainting couches" for this very reason.
waist training

Word to the wise, if you’re wearing a waist trainer and you experience any of above mentioned symptoms, that’s a definite sign that you need to loosen it up or take it off.

Practicing The Trend While Working Out— Waist training trend encourages women to wear the corset while working out! According to fitness experts, this is a huge no-no as our bodies need as much oxygen as possible during cardio and the use of restrictive garments prevents your lungs from expanding fully. In fact, some experts believe that regularly wearing a waist trainer can actually decrease core strength— exactly the opposite of what you want if you’re aiming for sexy stomach musculature.

Lilly James Verdict On The Corset — in Cinders own words, "If you ate food it didn't really digest properly, and I'd be burping all afternoon and it was just really sort of unpleasant". She actually went on a liquid diet to survive shooting through the movie to be able to fit into the ultra-constricting corset.
waist training

Final Verdict— Waist trainers can’t have any lasting effect on waist size, shape, or appearance. They’ll make you look slimmer while you wear them, but you may have to put up with some discomfort and maybe even some health risks in return. You're better off eating a balanced diet and investing in a personal trainer. After all, there's a reason we stopped wearing gowns with corsets in the 19th century!

Sure Shot Way To Shed Pounds Around Your Belly You guessed it — eating healthy and being active on a regular basis. It’s not trendy, but it’s the one thing that works, whether you want to drop baby weight or just a few stubborn lbs.

25.11.15

The A List Antiaging Secret — The UltraLift


Ultralift, Ultrasound assisted facelift
Thanks to a steady diet of lasers, lights, RF, and needles, middle-aged celebs have been defying aging with legitimate denials of surgical interventions.  How do they stay so youthful and fresh beyond their years is not a big SECRET anymore — Forget diamonds a dermatologist is a celeb’s best friend these days!

Talking about secrets — minimally invasive, no downtime, lunch-time procedures are what A-list celebs are relaying on these days to maintain their youthful image and skin. These are real exciting times for anti-aging medicine, the modern day anti-aging experts are armed, ready, and able to deliver revolutionary yet natural results — knives are being shelved and instead cutting edge devices are emerging as new youth dispensing heros. One such technology generating the loudest buzz in A-List anti-aging circles is: high intensity focused Ultrasound waves (HIFU to be more precise) — sound waves whispering youth into the aging skin (literally).

Yup, ultrasound facials my youthistas are the latest trend in lunch-hour high-tech treatments., these sessions comes with a solemn promise (backed by medical studies) to wipe years off of any visage with zero down time. The unique Ultralift (ultrasound assisted facelift) tightens the skin as well as the deeper support layer below it, without cutting or disrupting the surface of the skin. Rumored to be a favorite of Courtney Cox this technology holds the strongest promise yet to reduce fine lines, firm sagging skin and tackle open pores and pigmentation marks.

Let’s You Up Close & Personal With The UltraLift

The UltraLift is a non-surgical face, neck and body treatment that uses ultrasound to actually lift and tone loose skin without any downtime. It is a truly revolutionary treatment that can specifically target the SMAS; the deep foundation below the skin that is addressed during facelift surgery without cutting or disrupting the surface of the skin. 


Here are some questions that most people want to know about this latest nonsurgical facelift, before they consider test-driving the procedure personally.

How is The UltraLift different from Lasers and Radiofrequency technologies?

Lasers and RF technologies typically address issues in the superficial layers of the skin (e.g. fine lines, wrinkles, pigment changes). The focused ultrasound technology can address the skin as well as the deeper layer called SMAS, which makes the foundational muscle layer that drapes and lends support to the skin. The UltraLift therefore can provide more powerful lifting effect when compared to other technologies. Lasers in particular target pigment tissue of skin making some treatments in skin of color a little risky. Ultrasound on the other hand is not absorbed by the pigment elements of skin allowing treatments for even darker skin types more safely without any pigmentation related side effects

Who is a good candidate for The UltraLift?

Ultheraoy, ULtrasound facial

A good candidate for The UltraLift is someone with early to medium signs of aging someone with skin that feels less firm and looks sagging. A lowered brow line or sagging skin on the eyelids, for instance, is often the first sign of "aging", ill-defined jaw-line with hanging jowls, deepening marionette lines and laugh lines and sagging cheeks can all be addressed with Ultralift. While The Ultralift is not a replacement for surgery, there are many people who want some lifting but are not ready for surgery either mentally, financially or logistically.

What To Expect After The UltraLift Treatment?

Immediately after the procedure there is mild redness and swelling which subsides in few hours. Most people enjoy this edema as an initial lifting effect, but the ultimate lifting and toning takes place over the next 2-3 months, as tired and damaged collagen is renewed and replaced with new and stronger collagen. When eye area is treated it takes 3-7 days for the swelling to subside.

Is there any downtime with The UltraLift treatment?

With UltraLift, there is no downtime, most people are able to return to their normal activities right away, and no special measures are needed. It also can be carried out at any time of the year with no restrictions, with regard to sun exposure.

Will I feel the ultrasound during the treatment?

Yes. What you are feeling during the treatment is actually tiny amounts of concentrated ultrasound energy (micro coagulation zones) being deposited below the surface of the skin. While treating bony areas (jawline, cheek bones, bony area above eyes) there can be some discomfort while the energy is being delivered, but it is temporary and a positive signal that the collagen-building process has been initiated.

Remembering Thermage Is The UtraLift painful?

Usually a numbing cream is applied half an hour before the procedure, which makes the procedure relatively painless. Some people feel no discomfort at all, on the other hand some people who are more sensitive with very low pain threshold feel the procedure is uncomfortable but tolerable. In such sensitive cases oral ibuprofen or a nerve block might be used to make the procedure more acceptable. My personal experience — patients typically leave comfortable and excited about the benefits to come.

Are there any side effects?

There may be slight redness for up to an hour or so following the treatment, and a small percentage of people may have slight swelling, tingling or tenderness to touch, but these are mild and temporary in nature. There is always the possibility for other less common post-procedural effects, which your doctor will review with you in detail before the procedure.

How long does it take to perform The UltraLift?

A full face-and-neck treatment takes approximately 60 minutes, and a partial face treatment can take around 30-minutes.

What will my skin feel like after the procedure?

Immediately following the UltraLift procedure your skin should feel tighter, smoother and more youthful. Over time (2-3 months) you may notice additional tightening. The most frequently reported incidents are as follows and they all resolve within a few days of treatment:
·      Redness
·      Swelling
·      Tingling of the skin
·      Tenderness
·      Bruising

What areas can be treated with UltraLift?

The UltraLift is perfect for tightening and lifting the skin on the neck, under the chin, the jawline, the brow, around the eyes, and treating wrinkling and sagging on the décolletage and body (areas of which that can be targeted include: chest, arms, armpits, abdomen, flanks, thighs and lower legs).

How long before I can return to my normal activities?

Most people can return to their regular activities immediately following the UltraLift procedure. You should avoid exposing your skin to extremes of heat and cold and protect your skin with a sun block cream. Your normal makeup regime can be followed immediately.

Important Question Everyone Is Thinking About - Is The UltraLift safe?

After demonstrating safety in clinical studies, the device and the procedure have been cleared by the U.S FDA. Tens of thousands of treatments have been performed worldwide without any significant adverse events. In addition, ultrasound energy has a proven track record, with use in the field of medicine for more than 50 years, including pregnancy scans.

3.11.15

Chasing The Curse Of Sweaty Armpits


Hyperhydrosis, Excessive sweating
WE ALL sweat…. it is an essential process through which our body regulates temperature, but in certain genetically predisposed individuals (1-5% of population) perspiration can get so excessive that it cannot be controlled by even the strongest antiperspirants. In such cases that are sweating bullets constantly the drenched armpits exhibit the tell tale and embarrassing hallmark of “focal excessive sweating”. The prospect of ugly sweat patches appearing on clothes all the time can make any person very self-conscious and constantly battling with such a condition can eventually affect work as well as other social aspects of life. Today we’ll get you comfortable with the condition and introduce you to remedies that are available to function sweat free.

Hyperhidrosis is the medical name for such abnormally excessive sweating. It mostly affects the armpits, hands and feet.

Why I Sweat All The Time? It is thought that the nerves that trigger sweating malfunction causing the sweat glands to produce much more than required. What causes them to malfunction is not clear but up to two thirds of patients have a family history of the disorder suggesting, it may have a genetic cause and the trait usually appears after adolescence.

Secondary hyperhidrosis can also be triggered by some medications such as the antidepressant venlafaxine, the breast cancer treatment tamoxifen, and gonadotrophin-releasing hormone antagonists, a class of drugs used to treat fertility problems and prostate cancer.

Fighting Excessive Sweating

Hyperhydrosis Treatments excessive sweating

Standard Treatments include strong “prescription-only antiperspirants” and drugs such as propantheline or oxybutynin that work by blocking messages from the nerves that control the sweat glands. Unfortunately side effects of these medications can include a dry mouth, blurred vision, and problems with urination, hence they are not very popular for regular and long term use.

Iontophoresis works by sending low electronic waves through the skin passed through water or a wet pad, which helps to block the sweat glands. Mostly hands and feet are ideally treated by iontophoresis. Treating underarm hyperhidrosis with iontophoresis is not as common (although some people can have success with it) because the skin in the armpits is likely to be irritated by the process and because the physical structure of the underarms makes iontophoresis difficult to accomplish.

Sympathectomy Patients suffering from extreme sweating in some cases undergo an operation known as “Endoscopic Thoracic Sympathectomy”, which involves cutting into both armpits and collapsing the patient’s lung in the process to destroy the nerves activating the sweat glands in the armpit region. This is no doubt a risky surgical procedure and that’s why a very few number of patients opt for such an extreme measure to zap sweating.

Botox Injections have transformed excessive sweat treatment options since the past few years. The procedure works and is quiet safe the only catch here is that the injections have to be repeated two to three times a year and the cost of the procedure is on the expensive side.

Laser Dry is a minimally invasive and relatively quick procedure, which has become quiet popular among hyperhydrosis patients since the past 3-5 years. It takes less than an hour or so to perform, a solution containing a local anesthetic is infused into the fat layer of the skin in the axillary (armpit) area where the sweat glands are located. This fluid numbs the area locally. Next, a laser cannula measuring 2mm in diameter is inserted under the skin. The laser heats and melts the sweat glands and the surrounding fat, permanently reducing the ability of the sweat glands to produce sweat. The recovery from this procedure is quick and post-operative pain minimal. After the procedure patient has to wear a compression garment for 3-4 weeks and exercise is off limited for one week.

MiraDry is a new and quick procedure (1 – 1.5 hours) performed in a medical clinics, and it doesn't involve any surgical incisions or cuts. MiraDry works by delivering precisely controlled electromagnetic energy to the underarm area, eliminating the underarm sweat glands. Following local anaesthetic cream, the glands are suctioned to the surface and then eliminated after being blasted with electromagnetic waves. Patients need one or a maximum of two sessions for sweating to be stopped almost completely for ever. Done under expert hands side effects from Miradry are limited but those undergoing treatment are likely to experience swelling for several days. Patients are advised to put ice packs under their arms and take ibuprofen for 2-3 days.


12.10.15

Biologic Treatments In Dermatology Beyond Psoriasis


Bilologics in Dermatology
Here’s a very informative catalogue of the off-label use of biological drugs in Dermatology by Martinez Leborans et al. which was shared with the dermatological community as Poster at EADV Annual Meeting 2015 – Copenhagen, Denmark

The Off-Label Use Of Biological Drugs In Dermatology  - Our Experience In The Last 10 Years

Biologics have a targeted action against very specific molecules involved in the pathogenic mechanisms of the disease.
For instance, psoriasis treatments often target cytokines involved in the pathogenic pathway, such as Tumor-Necrosis Factor (TNF)

In this study from Spain spanning from 2002 to 2014, 45 different biologic drugs were given for off-label indications in 38 patients (25 male, mean age 41.7 years old)

In which indication were the biologics used ? (percentage of total)
-47% = hidradenitis suppurativa (HS; Verneuil’s disease)
-22% = pemphigus vulgaris (PV)
-11% = Pyoderma Gangrenosum
-9% = Atopic dermatitis (AD)
-3% = Behcet’s disease
-2% = Pityriasis Rubra Pilaris (PRP)
-2% = Psoriatic arthritis (PsA)
-2% = Eosinophilic Folliculitis (Ofuji’s disease)
-2% = Bullous Pemphigoid

Which biologics were used ? (percentage of total)
-44% = Infliximab (Remicade)
-24% = Rituximab (Mabtera, Rituxan)
–18% = Adalimumab (Humira)
-9% = Estekinumab (Stelara)
-5% = Etanercept (Enbrel)

What were the response rates ? (percentage of total)
-25% = total response
-37% = partial response
-20% = no response
-18% = loss of efficacy

Was it safe ?
1 patient had a severe adverse event (AE), and only 8 did not respond

Comments
-This study shows that biologics are given for off-label indications
-Although some biologics have shown indications for off-label treatments, there is no specific data shown in this study…it does however show that they are effective.